The project will be managed through a three-tiered structure..

(1) Steering Committee (SC) The SC consists of the highest-level managers of all the partner organizations. It approves and is responsible for:

(2) Workpackage Groups (WPGs) A WPG consists of the personnel appointed to a specific work package, (WP), and will be led by the WP Leader, (WPL).

(3) Project Coordinator The partner APHP will act as the Coordinator of the project, represented by the principal investigator and authorized contact person of APHP. APHP has an international track record of successfully managing large national and multi-national clinical research programs, collaborative projects, and evidence-based guideline elaboration. Project Management Team (PMT) APHP will appoint a Project Management Team (PMT), that will assist and report to the Project Coordinator.