Until 1997, the national register of Association France Hypophyse allowed the follow-up of children treated with growth hormone. Data collected through this register have allowed several epidemiological studies and have increased the knowledge on growth hormone treatments.

As discussed in the bacgkground for the SAGhE study, there is a need for additional data on the long term effects of growth hormone treatments. For this purpose, the French SAGhE study was started in 2007, in collaboration with AFSSAPS (Agence Française de Sécurité Sanitaire et des Produits de Santé, French Drug Agency), the Ministery of Health (DGS) and INCA. The aims of the study are to evaluate the long-term health of patients who have been treated with biosynthetic growth hormone in childhood. The national register of Association France Hypophyse made it possible to contact the patients and propose them to respond to a questionnaire on their health status. The SAGhE study in France has included 10489 patients.